The article considers the issue of updating personnel safety from the standpoint of the development of economic safety issues. The relevance of the problem of personnel safety has priority characteristics in the study of economic safety in general, as it considers human capital as an integral part of social and labor relations and clarifies the labor aspect of the activity on the formation of elements of society's stability from the standpoint of the implementation of economic activity processes within the framework of economic development trends. From the standpoint of the strategy, the target orientation of personnel safety can be considered as the formation of the personnel potential of the considered subject of economic relations of information, competence and other types of development in a competitive environment and the specifics of external factors of various market segments. In the article, the personnel safety of an organization is considered as one of the elements of anti-crisis management and internal corporate legal regulation. The author of the study considered the methodological aspect of the formation of key elements of the personnel safety structure necessary to ensure economic safety in general. When analyzing personnel safety, the author used competency-based, process and system approaches as a necessary set of methodological tools for scientific analysis of the problem under consideration. The article formulates a number of threats to personnel safety that can affect the economic safety of the organization as a whole. The position of the contribution of the author of the article is stated as the application of the considered approaches to individual threats to personnel safety. The proposed targeted application of methodological tools to personnel safety threats allowed the author of the article to formulate practical recommendations in the context of clarifying personnel policies, as well as determining and adjusting strategies for economic entities.